Özetle: The extent to which demographic-associated information is detectable across organs and disease states in routine clinical histopathology remains unclear.
Özet
The extent to which demographic-associated information is detectable across organs and disease states in routine clinical histopathology remains unclear. Here, we analyzed 1.3 million hematoxylin and eosin whole-slide images from 257,322 patients across 25 organs, using pathology foundation-model representations and multiple-instance learning to systematically map information associated with sex, age group, and self-reported race. Across 69 organ-demographic combinations, demographic attributes were broadly recoverable, with pan-organ mean AUROCs of 0.828 for sex, 0.733 for age group, and 0.662 for self-reported race, and substantial variation across organs. Demographic-class balancing produced relatively small changes in performance, while evaluation within diagnosis-text clusters showed modest attenuation. Under training with diagnosis-based grouping, demographic-associated signals remained detectable across multiple organs, including sex in gastric tissue (AUROC 0.865), age group in breast (0.816), and self-reported race in skin (0.728). Literature-guided analysis of these settings generated candidate histomorphological and contextual explanations for further investigation. Together, these findings provide a systematic map of demographic-associated information in routine histopathology, informing investigations of its sources, assessments of potential shortcut learning, and the development of more interpretable computational pathology models.
Orijinal Özet (İngilizce)
The extent to which demographic-associated information is detectable across organs and disease states in routine clinical histopathology remains unclear. Here, we analyzed 1.3 million hematoxylin and eosin whole-slide images from 257,322 patients across 25 organs, using pathology foundation-model representations and multiple-instance learning to systematically map information associated with sex, age group, and self-reported race. Across 69 organ-demographic combinations, demographic attributes were broadly recoverable, with pan-organ mean AUROCs of 0.828 for sex, 0.733 for age group, and 0.662 for self-reported race, and substantial variation across organs. Demographic-class balancing produced relatively small changes in performance, while evaluation within diagnosis-text clusters showed modest attenuation. Under training with diagnosis-based grouping, demographic-associated signals remained detectable across multiple organs, including sex in gastric tissue (AUROC 0.865), age group in breast (0.816), and self-reported race in skin (0.728). Literature-guided analysis of these settings generated candidate histomorphological and contextual explanations for further investigation. Together, these findings provide a systematic map of demographic-associated information in routine histopathology, informing investigations of its sources, assessments of potential shortcut learning, and the development of more interpretable computational pathology models.
Kaynak: arXiv:2611.09851 · PDF
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